You can literally pack it on and it looks real because (a concept we’ll come back to often) or body, it’s amazing how heavily The thing is, once you find aĬolor of makeup that repeats a color already in your face If you blot if well and apply a gloss over top, the color left behind is quite lovely, again for darker women.Īre you looking at these thinking “I thought she Mary Kay Amber Suede appears more orange and it goes on very dark and pigmented. If it seems too pink, try Whipped Berries, warmed up just a little but so slightly foggier and darker, for darker women. Now you need a plum-violet color: Mary Kay Berry Kiss is about as blue-pink as you can go, but this is a nice one (bluer, pinker, and brighter than the picture below). Is gorgeous in texture and durability, as are all NARS glosses. Vita Sheer Lipstick and lipgloss are good cool coral colors the gloss Look for icy pale colours.Ĭhristine on Deep/dark Winter From a Greener Tea Colors If you want to try a little shimmer here, it can work. Steel looks close.Įye hilite : PC Cream and Shell. I asked a woman wearing this the name of the colourīut I don’t see it at Mary Kay’s site. Brown gets muddy in a hurry on these people, but a sharp Mary Kay Crystalline and Onyx duet, very nice. This woman is doing a better job than the makeup companies themselves. Wash of real red on Winter skin is awesome.Įyeliner: MUFE Aqua Eyes Waterproof eyeliner 1L MAC Suite Array Pearlglide liner in Black Russian Clinique Quickliner in Black Brown.Įyeshadow: Stila Kalahoo, Kamet, Shore, Storm, and Nanda Devi at TNBTTGSY. Not made because nobody would be confident enough to buy it, but a sheer Does anyone know of a pure red blush? It’s What I would really like to find is a pure red blush. MAC Slimshine in Urgent is too.īlush: NARS Sin MAC Pink Swoon, Coygirl. Pure red and pure black also carry too much emotional signal, at It is hard looking because these are dark, cold, strongĬolors. I think red lips are about as wearable IRL as black eyeliner, which Lipstick: Estee Lauder Gloss Stick in Wild Plum ĮL Long Last in Red Apple EL Signature in Lush Rose. EL’s Lucidity Translucent powder in Medium Deep and Deep, depending on your skin tone, would be worth a try. Use it more as a contour but don’t use a lot. Estee Lauder Bronze Goddess Soft Matte Bronzer (not the duo) may be good. Skin more believably because there is a little warmth in the skin With a little Autumn or Spring and can carry a little warming of the Skin Tone: Porcelain, ivory, beige, clear oliveĬhristine on Cool or True Winter from a Greener Tea: Strawberry, true reds, clear not dark plum Makeup Tips for Clear Winter from CMB-LYB Skin Tone: Ivory, clear olive, cool beige Hair: Silver grey, salt ‘n pepper, black-grey Highlighter: Soft pink, icy grey, lemon, champagne Skin Tone: Black, cool brown, olive, cool beige Highlighter: Apricot, Lemon, Champagne, MintĬontour: Black-Brown, Grey, Purple, Spruce, Olive, Aubergine Shadow for deep brown, hazel or olive eyes From Color Me Beautiful's Looking Your Best
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Structural and immunological characterization of hydroxyl radical modified human IgG: Clinical correlation in rheumatoid arthritis Moreover, the high frequency of occurrence of IgG4 AKA might result from chronic exposure to the eliciting antigen, which could be a genuine autoantigen since we demonstrated that it is also present in the stratum corneum of human epidermis. The large predominance of IgG1 AKA and the quasi-absence of IgG2 AKA suggest that the recognized antigen may be partly comprised of protein. In spite of inter-individual heterogeneity, two predominant profiles were distinguished: IgG1 (alone) and IgG(1 + 4), which together represented 18 sera (58%). IgG1,2,3, and 4 AKA were detected in 27 (87%), 6 (19%), 4 (13%) and 11 (35%) of the 31 rheumatoid sera, respectively, and were found to be independent of the clinical and biological indices of the disease. In the rheumatoid sera, the serum level of IgG1 was found to be significantly increased and the level of IgG2 significantly decreased with regard to the control sera, while the levels of IgG3 and 4 as well as total IgG were in the normal range. The serum level of IgG1,2,3 and 4 was determined by radial immunodiffusion and the subclass distribution of IgG AKA by a three-step semi-quantitative immunofluorescence assay using standard monoclonal antibodies specific for each of the four human IgG subclasses. In this study, we investigated 31 IgG AKA-positive rheumatoid sera and 21 control sera from patients with non- rheumatoid inflammatory rheumatic diseases. Serum IgG, labelling the stratum corneum of the rat oesophagus epithelium, so-called anti-keratin antibodies (AKA) constitute the most specific marker for the diagnosis of rheumatoid arthritis. Vincent, C Serre, G Basile, J P Lestra, H C Girbal, E Sebbag, M Soleilhavoup, J P Subclass distribution of IgG antibodies to the rat oesophagus stratum corneum (so-called anti-keratin antibodies) in rheumatoid arthritis. Application of the polymerase chain reaction (PCR), using probes specific for the nucleotide sequence coding for the Gm(a) tetrapeptide, to the amplification of DNA from the in In most instances, these PBMC produced IgG that behaved as Gm(a+) in sensitive ELISA. To investigate the molecular basis of the acquired Gm(a) phenotype, PBMC from five Gm(a−) patients with rheumatoid arthritis and two Gm(a−) normal subjects were cultured in vitro after activation with PWM. RF mAb 61 displayed a high affinity (Kd, 10−7 M) for IgG Fc fragment of Gm(a+) and (g+) IgG or aggregated autologous Gm(a−), (g−) IgG but did not bind to native autologous IgG. That heterocliticity and dual Gm(a), Gm(g) specificity can be features of a single antibody molecule was formally demonstrated by analysis of a monoclonal RF (IgM mAb 61) generated from a Gm(a−), (g−) rheumatoid patient. Heat aggregation (63Â☌ for 20 min) or binding to Ag (as in tetanus toxoid-antitetanus toxoid complexes) induced a “functional†Gm(a+) and/or (g+) phenotype in Gm(a−), (g−) IgG from five healthy subjects and five rheumatoid patients, as suggested by the ability of these altered IgG to function as efficient targets for six heteroclitic RF in direct binding and competitive inhibition experiments. To investigate possible mechanisms underlying the in vivo generation of heteroclitic RF, we tested the ability of non-specifically and immune-specifically aggregated Gm(a−), (g−) IgG to function as targets for RF from Gm(a−), (g−) patients with rheumatoid arthritis. All polyclonal RF we isolated from nine rheumatoid arthritis patients with circulating Gm(a−), (b+), (g−), (f+) IgG displayed dual heteroclitic activity for the Gm(a) and Gm(g) allotypes, as shown by using appropriate RBC agglutination assays and affinity columns bearing Gm(a+) or Gm(g+) IgG. Heteroclitic rheumatoid factors (RF) are specific for allotypic determinants, e.g., Gm(a) or Gm(g) on allogeneic, but not autologous IgG. HETEROCLITIC POLYCLONAL AND MONOCLONAL ANTI-Gm(a) AND ANTI-Gm(g) HUMAN RHEUMATOID FACTORS REACT WITH EPITOPES INDUCED IN Gm(a−) Gm(g−) IgG BY INTERACTION WITH ANTIGEN OR BY NONSPECIFIC AGGREGATION How to save on Online EducationĪlthough many online programs help you save as compared to traditional courses, you can save even more by following some smart ways. E-learning will keep your kids engaged and keep the white noise away from their lives. You can also monitor the progress of your kids by preparing study maps, milestones, and more with the online tools. 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Steward will lead Fury into their third bout together, a world title defence against domestic rival Whyte. Which makes us even better than we were if we had not been through those things." We all have to have some kind of - I don't want to say struggle - but we have to have gone through some things to get us to this point where we are now. "It goes for Tyson, myself, for everybody. You can't take away those experiences from anybody and put them in a position that they're in now because they wouldn't be the same person without those experiences in life. "That's the part of growing and learning in life. Steward says: "Tyson needed and had to go through certain things in his life to bring him to where he is now, to help and to be able to handle situations a lot differently. Fury hopes that by spreading mental health awareness can positively affect Calm's sobering statistics. In 2021 Calm reported that 115 people die by suicide in the UK every week - with 75% of those deaths being male. The commercial carried the message: "Sometimes the toughest opponents are the ones you can't see - don't suffer alone." Steward joined Fury's team before the second fight with Deontay Wilder Last year, the 33-year-old teamed up with suicide prevention charity Campaign Against Living Miserably (Calm) to release an advert. As a result, Fury now uses his platform to encourage people to reach out for help if they are struggling. Not just to us, but to other people and being able to help other people."Īt the depth of his depression, Fury had suicidal thoughts.Ī psychologist helped the undefeated champion to understand the feelings he was experiencing. "Those things we go through are powerful. "Had he not gone through it, then what? We wouldn't be talking about the same Tyson Fury. Sport warned about involvement with Fury-linked Kinahan.'No links' between Kinahan and Probellum."Now to be able to reach out and touch and help so many people in that manner, because he went through it. "If Tyson didn't go through what he went through, then how would he be able to help other people mentally if he hadn't gone through it?" he says. Now a world champion again as the WBC belt holder and preparing to face Dillian Whyte at Wembley on 23 April, Fury has grown from his troubles, according to Steward. He was diagnosed in 2016.įor roughly two years after his world title triumph over Wladimir Klitschko in Germany in 2015, Fury admitted to losing his passion for life. He became aware of his condition after feelings of worthlessness, anxiety and severe depression reduced him to his lowest ebb. Fury defends his WBC title against Dillian Whyte at Wembleyįury is bipolar, a disorder that can trigger mood changes. We help each other out - not knowing that we're helping each other out. "We have that smooth balance like caramel and chocolate. So me and him are very comfortable in our situation - and in any situation - because we feed off of each other. "I just allow Tyson to be himself and it's the same for me - I'm being myself. And he's watching me, trying to understand me - so we can help fill each other's many ups and downs if you want to call them ups and downs. "I'm watching him, trying to understand him. "If you're in a relationship with somebody, or if you have kids - parents know when their kids are not feeling well because they're watching them and they're trying to understand them. We just feel it in each other," Steward tells BBC Sport. Under the American's guidance, Fury dispatched knockout artist Deontay Wilder in back-to-back world title fights.Īnd outside the ropes - where the mind can get stuck in the past or lost in what might happen in the future - Steward has also become attuned to Fury's mental health needs. Steward has turned Briton Fury, who has been open about his mental health challenges, into an aggressive puncher in the two years that they have worked together. 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Initial Details on Using Driver’s Licenses and State ID’s in Apple Wallet 1 Sep 2021 August 2021 Why iPhone Names Have Numbers and Most Other Apple Product Names Don’t 9 Sep 2021 Various Single-Paragraph Thoughts and Observations Regarding Yesterday’s ‘California Streaming’ Apple Event for the iPhones 13, Apple Watch Series 7, and New iPads 15 Sep 2021 Why Does the iPhone Still Use Lightning? 27 Sep 2021Īpple Will Not Reinstate Epic’s Fortnite Developer Account, but Epic’s Other Developer Accounts Remain Active 22 Sep 2021 The Tragedy of Safari 15 for Mac’s ‘Tabs’ 1 Oct 2021 September 2021 Last-Minutes Guesses for Today’s ‘Unleashed’ Event 18 Oct 2021 Tim Sweeney Says the Quiet Part Out Loud 24 Nov 2021Ī Few Follow-Up Points on Apple’s Self Service Repair Program 18 Nov 2021Īpple’s New Self Service Repair Program 17 Nov 2021Ĭraig Federighi’s Sideloading Keynote at Web Summit 16 Nov 2021 October 2021 The Algorithmic Ad Monster Cometh for Podcasts 6 Jan 2022 December 2021Īppeals Court Grants Apple a Delay on Injunction Mandating Changes to App Store in Epic Case 8 Dec 2021 November 2021 The App Store Is (Well, Was) Lousy With Blatant Wordle Rip-Offs, but One of Them Takes the Cake 11 Jan 2022 Leaker Sinks Peloton Stock With Confidential Information 21 Jan 2022įollow-Up on Yesterday’s 1Password Item 20 Jan 2022Ī Five-Letter Word for ‘Rip-Off’ 18 Jan 2022 Twitter’s Confusing New, but Hopefully Now Abandoned, ‘Home/Latest’ Timeline 14 Mar 2022 February 2022Ī Tale of Attempted Censorship in Three Acts 31 Jan 2022Īn Assortment of Links and Observations Regarding the Neil Young –Joe Rogan Spotify Saga 29 Jan 2022 Goes After Google’s ‘Communicate With Care’ Program 24 Mar 2022 Play Ball: Apple Announces More Details About ‘Friday Night Baseball’ on Opening Day 8 Apr 2022Īpple’s Dance With the Netherlands ACM Continues 6 Apr 2022 March 2022 More Rumors on Apple Obtaining the Rights to NFL Sunday Ticket 18 Apr 2022ģ0 Years of BBEdit Not Sucking 15 Apr 2022 Noted Interaction Design and Security Expert Margrethe Vestager Redesigns the iPhone’s NFC Support 4 May 2022 April 2022 The Grave Insult of Being Sent the Proper Tools to Perform a Complicated Task 26 May 2022 The Talk Show Live From WWDC 2022, With Craig Federighi and Greg Joswiak 10 Jun 2022īasic Apple Guy’s Prescient Reimagining of System Preferences on MacOS 9 Jun 20 German Regulators Open Investigation Into Apple’s App Tracking Transparency 14 Jun 2022 Two New Apps I Wanted to Flag for You 23 Jun 2022 How to Temporarily Disable Face ID or Touch ID, and Require a Passcode to Unlock Your iPhone or iPad 27 Jun 2022 IMessage Editing and Un-Sending in the Fourth iOS 16 and MacOS 13 Developer Betas 1 Aug 2022 July 2022 Is App Tracking Transparency Actually Doing Anything Truly Significant? 11 Aug 2022ĭropbox Branding and App Store SEO Shenanigans 5 Aug 2022 The Financial Times on the Effects of App Tracking Transparency on Small Businesses 12 Aug 2022 Thoughts and Observations on Last Week’s ‘Far Out’ Apple Event 13 Sep 2022Ī Quick Run-Through of Rumors and Speculation Ahead of This Wednesday’s ‘Far Out’ Event for the iPhones 14, New Apple Watch Models, and Who Knows What Else 6 Sep 2022 August 2022 The iPhones 14 Pro (and iPhones 14) 15 Sep 2022 The iPad Lineup Is, Like, Growing Out Its Bangs or Something and Looks a Little Weird Right Now, but Apple TV Has Been Going to the Gym and Looks Great 21 Oct 2022 The 2022 iPad (and a Wee Note About the 2022 iPad Pros) 26 Oct 2022 Previously, on Daring Fireball October 2022 Empire State Building Drone CrashĪfter the crash, Sean Riddle entered the building in an attempt to retrieve the aircraft. 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